Immune checkpoint inhibitors (ICPis) have revolutionized cancer therapy with broad activities against a wide range Set of malignancies.However, in many malignancies their efficacy remains limited due to the primary resistance.Furthermore, a high percentage of patients develop progression due to the secondary resistance even after obtaining a Body S
Hua Yang,1,* Jian Gao,2,* Shuyu Li,1 Huiling Xia,1 Zhangyan Chen,1 Shanzhu Zhu,1 Zhigang Pan1 1Department of General Practice, Zhongshan Hospital of Fudan University, Shanghai, 200030, People’s Republic of China; 2Department of Nutrition, Zhongshan Hospital of Fudan University, Center of Clinical Epidemiology and Evidence-Based Medicine, Fuda
Background: The potential effects of short-term exposure to major ambient gaseous pollutants (ozone: O3, carbon monoxide: CO, and sulfur dioxide: SO2) on platelet mitochondrial DNA (mtDNA) methylation have been uncertain and no studies have examined whether platelet mtDNA methylation levels could modify the associations between ambient gaseous poll
Alteration of the composition of soil organic matter (SOM) in Inner Mongolian grassland soils MAYAN MAGIC LITE associated with the duration of grazing exclusion (GE) has been considered an important index for evaluating the restoring effects of GE practice.By using five plots from a grassland succession series from free grazing to 31-year GE, we me